rapeutic Targeting of the DNA Mismatch Repair Pathway
نویسندگان
چکیده
wnloaded mismatch repair (MMR) pathway is involved in the removal of DNA base mismatches that arise during DNA replication or are caused by DNA damage. Mutations in four genes involved in MMR, , MLH1, PMS2 and MSH6, predispose to a range of tumorigenic conditions, including hereditary lyposis colon cancer, also known as Lynch syndrome. Here we discuss the canonical MMR pathway e burgeoning evidence for noncanonical roles for the MMR genes, and highlight the therapeutic ations of MMR. In particular, we discuss how the DNA repair defect in MMR-deficient cancers could implic be exploited by the development of novel therapeutic strategies based on synthetic lethal approaches.
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